WellSurvivor Breast BR-9
WellSurvivor Breast BR-9 is a multi-supplement routine specifically researched to support long-term nutritional needs and wellness goals of estrogen-positive, HER2-negative (ER+/HER2-) breast cancer survivors currently taking a SERM with a CDK 4/6 inhibitor.
Healthcare Provider Documentation & Information:
The information below is intended for healthcare provider reference only. It summarizes supporting clinical research, ingredient rationale, and evidence-based considerations relevant to professional evaluation. This content is not intended for customer-facing use. This content is for informational and educational purposes only.
Bone Health
Vitamin D₃ (3,000 IU), Vitamin K₂ (100 µg), Magnesium (Bisglycinate 90 mg), Calcium Citrate (160 mg)
• Supports bone density & calcium balance — Endocrine guidelines emphasize sufficient calcium & vitamin D for skeletal health maintenance. endocrine.org+1
• Breast cancer treatments like chemotherapy-induced menopause and ovarian suppression accelerate bone loss; guidelines advocate calcium + vitamin D supplementation to prevent osteoporosis. endocrine.org
• Vitamin K₂ enhances vitamin D’s effect on bone mineralization: meta-analysis shows K₂ improves lumbar spine BMD and reduces fracture risk. PMC9403798
• Higher magnesium intake associated with higher bone mineral density (BMD) PubMed 34666201
• These nutrients are non-estrogenic at these doses; no evidence of activating ER+ pathways.
Immune Function & Wellness (Medicinal Mushrooms)
Turkey Tail, Reishi, Maitake, Lion’s Mane, Cordyceps, Chaga, Oyster (standardized extracts)
• β-Glucans enhance immune surveillance by binding to receptors (Dectin 1, CR3, TLR-2/6) on macrophages & NK cells PubMed 19515245, PMC10711352.
• Turkey Tail Phase I trial: safe up to 9 g/day, improved lymphocyte & NK function DOI 10.5402/2012/251632.
• Reishi improved fatigue & QOL in endocrine-therapy survivors PubMed 22203880; Maitake improved immune signaling PubMed 19253021.
• Lion’s Mane improved cognition PubMed 18844328; Cordyceps review supports immune modulation PMC9572669; Chaga induces autophagy DOI 10.1016/j.jep.2021.114081; Oyster β-glucan increased T-cell counts PubMed 34784798.
• Non-estrogenic; safe alongside hormonal therapies; mild GI upset possible.
Stress Resilience & Energy
Rhodiola rosea (250 mg)
• Adaptogen improving fatigue, stress, and cognition PMC6208354.
• Salidroside induces apoptosis and cell-cycle arrest in breast cancer cells ScienceDirect.
• Cardioprotection: reduced cardiac injury markers in anthracycline trials PubMed 22770377.
• Non-Estrogenic; does not interfere with endocrine therapy AACR.