WellSurvivor Breast BR-8
WellSurvivor Breast BR-8 is a multi-supplement routine specifically researched to support long-term nutritional needs and wellness goals of estrogen-positive, HER2-negative (ER+/HER2-) breast cancer survivors currently taking a SERM.
Healthcare Provider Documentation & Information:
The information below is intended for healthcare provider reference only. It summarizes supporting clinical research, ingredient rationale, and evidence-based considerations relevant to professional evaluation. This content is not intended for customer-facing use. This content is for informational and educational purposes only.
Bone Health
Vitamin D₃ (2,000 IU), Vitamin K₂ (100 µg), Magnesium (Bisglycinate 90 mg)
• Supports bone density & calcium balance — Endocrine guidelines emphasize sufficient calcium & vitamin D for skeletal health maintenance. endocrine.org+1
• Breast cancer treatments like chemotherapy-induced menopause and ovarian suppression accelerate bone loss; guidelines advocate calcium + vitamin D supplementation to prevent osteoporosis. endocrine.org
• Vitamin K₂ enhances vitamin D’s effect on bone mineralization: meta-analysis shows K₂ improves lumbar spine BMD and, when heterogeneity is accounted for, reduces fracture risk. PMC9403798
• Higher magnesium intake was associated with higher bone mineral density (BMD) PubMed 34666201
• These nutrients are non-estrogenic at these doses; no evidence of activating ER+ breast cancer pathways from these levels.
Metabolic & Thyroid Function (Trace Minerals)
Zinc (8 mg), Selenium (50 µg), Iodine (50 µg), Manganese (1 mg), Chromium (100 µg), Molybdenum (45 µg)
• Core enzyme cofactors — Zinc → Cu/Zn-SOD (SOD1) supports cellular antioxidant defense PubMed 29186856
• Manganese → Mn-SOD (SOD2) is the chief mitochondrial ROS scavenger PubMed 22072939
• Selenium → selenoproteins (GPx, TrxR, deiodinases) linking redox control, immunity, and thyroid metabolism PubMed 22072939
• Molybdenum → cofactor for xanthine oxidase, sulfite oxidase, aldehyde oxidase (NIH ODS fact sheet for clinicians).
• Thyroid hormone synthesis (iodine): Iodine is required for T4/T3 production; adult RDA ≈150 µg/day and UL 1,100 µg/day (NIH ODS Iodine).
• Selenium & cancer-relevant outcomes: Higher selenium status is associated with lower overall cancer risk PubMed 26786590. Lower serum selenium/SELENOP relates to worse survival PubMed 33809461, PubMed 29043463.
• Iodine & breast tissue: Clinical studies in fibrocystic breast disease show symptomatic benefit with iodine PubMed 8221402, PMC11700310
• HR⁺ survivorship context: At physiologic (RDA/AI) doses, these trace minerals are non-estrogenic and commonly used in survivorship care; guideline frameworks from SIO–ASCO emphasize evidence-based, low-risk integrative strategies and avoiding non-indicated high-dose supplements.
Antioxidant & Cellular Protection
Vitamin C (300 mg), EGCG (Green Tea Extract) 400 mg, Lycopene (8 mg)
• Vitamin C: Potent antioxidant and immune supporter; facilitates collagen synthesis and wound healing. PMC5707683
• EGCG: Large meta-analysis showed potential reduction in breast cancer risk DOI 10.3390/nu10121886; does not alter tamoxifen metabolism PMC7595994.
• Lycopene: Pro-apoptotic carotenoid; induces cell-cycle arrest in both ER+ and ER- lines PMC4317951, PMC9741066.
Immune Function & Wellness (Medicinal Mushrooms)
Turkey Tail, Reishi, Maitake, Lion’s Mane, Cordyceps, Chaga, Oyster (standardized extracts)
• β-Glucans enhance immune surveillance via macrophage/NK activation PubMed 19515245; activate Dectin-1, CR3, TLR-2/6 pathways PMC10711352.
• Turkey Tail Phase I trial in breast cancer survivors showed improved NK cell function Turkey Tail Trial.
• Reishi improved fatigue and quality of life PubMed 22203880; Maitake Phase I/II demonstrated immune signaling benefits PubMed 19253021.
• Lion’s Mane RCT improved cognition PubMed 18844328; Cordyceps review supports immunomodulation PMC9572669; Chaga induces autophagy DOI 10.1016/j.jep.2021.114081; Oyster β-glucan increased T-cell counts PubMed 34784798.
• Safety: These mushroom extracts are non-estrogenic and have no phytoestrogen content. No adverse interactions with hormonal therapies have been reported. They primarily act via immune modulation, not hormone pathways.
Stress Resilience & Energy
Rhodiola rosea (250 mg)
• Adaptogen: Supports fatigue, mood, and cognitive performance PMC6208354.
• Salidroside: Induces apoptosis and cell-cycle arrest in breast cancer lines without estrogenic activity ScienceDirect.
• Cardioprotection: Reduces chemo-related cardiac injury in early studies PubMed 22770377.
• Non-Estrogenic: No hormonal activity or interference with endocrine therapies AACR.