WellSurvivor Breast BR-6
WellSurvivor Breast BR-6 is a multi-supplement routine specifically researched to support long-term nutritional needs and wellness goals of estrogen-negative (ER-) DCIS/LCIS survivors who are not currently taking any maintenance medications.
Healthcare Provider Documentation & Information:
The information below is intended for healthcare provider reference only. It summarizes supporting clinical research, ingredient rationale, and evidence-based considerations relevant to professional evaluation. This content is not intended for customer-facing use. This content is for informational and educational purposes only.
Bone Health
Vitamin D₃ (2,000 IU), Vitamin K₂ (100 µg), Magnesium (Bisglycinate 90 mg)
• Supports bone density & calcium balance — Endocrine guidelines emphasize sufficient calcium & vitamin D for skeletal health maintenance. endocrine.org+1
• Breast cancer treatments like chemotherapy-induced menopause and ovarian suppression accelerate bone loss; guidelines advocate calcium + vitamin D supplementation to prevent osteoporosis. endocrine.org
• Vitamin K₂ enhances vitamin D’s effect on bone mineralization: meta-analysis shows K₂ improves lumbar spine BMD and, when heterogeneity is accounted for, reduces fracture risk. PMC9403798
• Higher magnesium intake was associated with higher bone mineral density (BMD) PubMed 34666201
Metabolic & Thyroid Function (Trace Minerals)
Zinc (8 mg), Selenium (50 µg), Iodine (50 µg), Manganese (1 mg), Chromium (100 µg), Molybdenum (45 µg)
• Core enzyme cofactors — Zinc → Cu/Zn-SOD (SOD1) supports cellular antioxidant defense PubMed 29186856
• Manganese → Mn-SOD (SOD2) is the chief mitochondrial ROS scavenger PubMed 22072939
• Selenium → selenoproteins (GPx, TrxR, deiodinases) linking redox control, immunity, and thyroid metabolism PubMed 22072939
• Molybdenum → cofactor for xanthine oxidase, sulfite oxidase, aldehyde oxidase (NIH ODS fact sheet for clinicians).
• Thyroid hormone synthesis (iodine): Iodine is required for T4/T3 production; adult RDA ≈150 µg/day and UL 1,100 µg/day (NIH ODS Iodine).
• Selenium & cancer-relevant outcomes: Higher selenium status is associated with lower overall cancer risk PubMed 26786590. Lower serum selenium/SELENOP relates to worse survival PubMed 33809461, PubMed 29043463.
• Iodine & breast tissue: Clinical studies in fibrocystic breast disease show symptomatic benefit with iodine PubMed 8221402, PMC11700310
Antioxidant & Cellular Protection
Vitamin C (300 mg), EGCG (Green Tea Extract) 400 mg, Lycopene (8 mg), DIM (Diindolylmethane) 150 mg
• Vitamin C: Potent antioxidant and immune supporter; facilitates collagen synthesis and wound healing. PMC5707683
• EGCG: Large meta-analysis showed potential reduction in breast cancer risk DOI 10.3390/nu10121886; does not alter tamoxifen metabolism PMC7595994; induces apoptosis in ER- cells AACR Study.
• Lycopene: Pro-apoptotic carotenoid; induces cell-cycle arrest in both ER+ and ER- lines PMC4317951, PMC9741066.
• DIM: Supports healthy estrogen metabolism and inhibits proliferation independent of ER status PMC5059820, PubMed 11931841
Immune Function & Wellness (Medicinal Mushrooms)
Turkey Tail, Reishi, Maitake, Lion’s Mane, Cordyceps, Chaga, Oyster (standardized extracts)
• β-Glucans enhance immune surveillance via macrophage/NK activation PubMed 19515245; activate Dectin-1, CR3, TLR-2/6 pathways PMC10711352.
• Turkey Tail Phase I trial in breast cancer survivors showed improved NK cell function Turkey Tail Trial.
• Reishi improved fatigue and quality of life PubMed 22203880; Maitake Phase I/II demonstrated immune signaling benefits PubMed 19253021.
• Lion’s Mane RCT improved cognition PubMed 18844328; Cordyceps review supports immunomodulation PMC9572669; Chaga induces autophagy DOI 10.1016/j.jep.2021.114081; Oyster β-glucan increased T-cell counts PubMed 34784798.
Stress Resilience
• Ashwagandha: Reduced stress & fatigue in RCTs; improved QOL in survivorship NIH ODS, MSK Summary
• Apigenin: Chamomile extract trials show anxiolytic & sleep benefits Frontiers 2024, PMC6472148; preclinical data support ERα degradation and TNBC stem cell suppression PMC2559959, Nature Cell Death 2018.
• Mangosteen: Reduced CRP and oxidative stress in human trials PubMed 26286710; reviewed by MSK as adjunct support MSK Mangosteen.